Breathe In Breathe Out
performed by Mat Kearney

Having just returned from her honeymoon with Meredith, Cristina searches for Burke, but he is nowhere to be found. Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns. Among the interns are George, repeating his intern year after failing his exams, as is Lexie Grey, Meredith's half-sister whom she has never met. Now that Derek's relationship with Meredith has reached an emotional impasse, he looks to his fellow doctors for friendship; Bailey wrestles with her place within the hospital now that her former interns report to new Chief Resident Callie; and Richard resumes his position as Chief of Surgery.

Liz encounters the man of her dreams while dealing with the weddings of Cerie, Floyd, and Grizz. Jack is forced to choose between Avery and Nancy. Another woman comes between Jenna and her boyfriend. Kenneth fears receiving a promotion that would move him to Los Angeles.