Each episode is divided into segments of varying length - sketches, stand-up bits, street interviews and longer interviews with an unusual personality, often regarding sexuality and gender roles. Amy Schumer is the only actor featured in every episode and each segment. Comedy Central airs two versions of the series; the regular version for prime time and earlier airings rated TV-14 with profanity bleeped, along with a late night 'uncensored' version rated TV-MA-L with no censoring at all.

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