This Movie Series is referred to by Brian Writes a Bestseller part of Family Guy Season 9
Stewie promises Brian he will be as quiet as a man in a coma. The scene cuts away to a man in a coma, who is relieved to be alone with just his own thoughts. He starts imagining great movie ideas, and comes up with the thought of creating a Predator vs. Superman movie.
The Predator film series is a science fiction horror film franchise, focusing on a human superior (who changes in each film) and their battle with an extraterrestrial lifeform, the Predator, as it gradually picks off his allies.