Something to Talk About
performed by Andy Samberg and Scarlett Johansson

Grace Bichon, who is managing her father's riding-stable, discovers that her husband Eddie deceives her with another woman. After confronting him in the middle of the night on the streets of their small home town, she decides to stay at her sister Emma Rae's house for a while, to make up her mind. Breaking out of her everyday life, she starts to question the authority of everyone, especially her father's, thus causing a stir in her parent's marriage, too

Cristina, Izzie and Meredith aggressively pursue the case of Shane, a male patient who seems to have a hysterical pregnancy, which fascinates them and the entire medical staff, and also angers Meredith because everyone in the hospital is not respecting the privacy of the patients. In a parallel situation, many hospital workers whisper continuously about Derek and Meredith and give them little privacy as well. A sheltered young patient inspires Alex to better express his feelings for Izzie. The episode ends with Alex arriving at the bar, pulling Izzie backwards and kissing her.

George and Lavon enlist Tansy's help to try to figure out why Filmore is interested in merging towns. Zoe concocts a fake story involving an affair between AnnaBeth and Joel in hopes to distract the townspeople before they find out about the potential merger. Wade and Vivian go on a date but she has second thoughts after speaking to Zoe about Wade. Shelby asks Brick for help with her pregnancy. Lemon is away taking care of her grandmother.